Significantly reducing blood loss via a peri-articular injection of tranexamic acid during total knee arthroplasty: a retrospective study

Abstract Background The administration of an intra-articular injection (IAI) tranexamic acid (TXA) has been demonstrated to be effective in reducing both blood loss and transfusion rate during total knee arthroplasty (TKA); however, few studies have reported the efficiency a peri-articular (PAI) TXA. We studied PAI TXA TKA. Methods Fifty patients undergoing primary simultaneous bilateral TKA were enrolled this retrospective study. right received 1 g (Group I), left IAI II). clinical outcome measures change from Hemovac drains surgical time. Results decrease was significantly lower Group I (460.1 ± 36.79 vs. 576.0 34.01, P < 0.001) than II, no significant difference times observed. present study 16 %. Conclusions A may reduce more efficiently without increased complications such as site infection, poor wound healing, skin necrosis, pulmonary embolism, deep vein thrombosis.